Elp1 - elongator complex protein 1 Gene

Also Known as IKAP; Ikbkap; 6030413P05; 3110040G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230233

Summary

Predicted to enable ATP binding activity; protein kinase activity; and tRNA binding activity. Predicted to be involved in I-kappaB phosphorylation and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and telencephalon. Used to study Riley-Day syndrome and hemophagocytic lymphohistiocytosis. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Elp1 Products (1)

mRNA Protein Name
NM_026079.3 NP_080355.2 elongator complex protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28507509 MGI
Biological Process GO Annotation Evidence References Source
involved in tRNA wobble uridine modification IMP
IMP: Inferred from mutant phenotype
23717213 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23717213 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elongator complex protein 1

  • IKK complex-associated protein

  • IKK-complex-associated protein IKAP

  • ikappaB kinase complex-associated protein

  • inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein

Elp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Elp1 Q7TT37 Gja1 Mus musculus P23242
Anti Bait CoIP
28507509
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148772 PTC258 Modulator 99.84% Unkown
HY-147149 BPN-15477 Modulator 99.92% Unkown
HY-W008753 Z-L-Val-OH 99.79% Unkown
HY-RS04328 ELP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07202 KDELR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22488 Epb41 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Elp1 NCBI NCBI:8518