Nptx1 - neuronal pentraxin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 266777

Summary

Predicted to enable metal ion binding activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of postsynaptic density assembly. Located in mitochondrion; neuron projection; and plasma membrane. Is active in glutamatergic synapse and synaptic cleft. Orthologous to human NPTX1 (neuronal pentraxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nptx1 Products (1)

mRNA	Protein	Name
NM_153735.4	NP_714957.1	neuronal pentraxin-1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	22427704	RGD
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	22279230	RGD
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22279230	RGD
involved in mitochondrial transport	IMP IMP: Inferred from mutant phenotype	22279230	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: Inferred from Experiment	29024665	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	29024665	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	29024665	RGD
involved in postsynaptic density assembly	EXP EXP: Inferred from Experiment	29024665	RGD
involved in postsynaptic density assembly	IDA IDA: Inferred from direct assay	29024665	RGD
involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	29024665	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	29024665	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29024665	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29024665	RGD
is active in synaptic cleft	IDA IDA: Inferred from direct assay	29024665	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuronal pentraxin-1	47 kDa taipoxin-binding protein NP-I NP1 neuronal pentraxin I

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09505	NPTX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19725	Nptx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26221	Nptx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nptx1	NCBI	NCBI:4884