POLE3 - DNA polymerase epsilon 3, accessory subunit Gene

Also Known as p17; YBL1; CHRAC2; CHRAC17; CHARAC17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54107

About POLE3

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,407,235-113,410,749 (from NCBI)

This gene has 4 transcripts (splice variants) and 98 orthologues. Ubiquitous expression in bone marrow (RPKM 36.1), testis (RPKM 24.6) and 25 other tissues.

Summary

POLE3 is a histone-fold protein that interacts with Other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

POLE3 Products (2)

mRNA Protein Name
NM_001278255.1 NP_001265184.1 DNA polymerase epsilon subunit 3
NM_017443.5 NP_059139.3 DNA polymerase epsilon subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10801849 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated DNA replication IDA
IDA: Inferred from direct assay
33051204 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
10880450 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18838386 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14759371 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
12434153 GOA
Cellular Component GO Annotation Evidence References Source
part of ATAC complex IDA
IDA: Inferred from direct assay
18838386 GOA
part of epsilon DNA polymerase complex IDA
IDA: Inferred from direct assay
10801849 GOA
part of epsilon DNA polymerase complex IPI
IPI: Inferred from physical interaction
10801849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLE3 Protein Structure

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (9 - 73)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

DNA polymerase epsilon subunit 3

  • CHRAC-17

POLE3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLE3 Q9NRF9 DKFZp666G145 Homo sapiens Q658N3
Y2H Array
25416956
Intra
POLE3 Q9NRF9 DKFZp666G145 Homo sapiens Q658N3
Y2H Prey Pooling
25416956
Intra
POLE3 Q9NRF9 CHRAC1 Homo sapiens Q9NRG0
Anti Tag CoIP
33961781
Intra
POLE3 Q9NRF9 CHRAC1 Homo sapiens Q9NRG0
Validated Y2H
32296183
Intra
POLE3 Q9NRF9 CHRAC1 Homo sapiens Q9NRG0
Y2H Prey Pooling
25416956
Intra
POLE3 Q9NRF9 CHRAC1 Homo sapiens Q9NRG0
Y2H Array
25416956
Cross
POLE3 Q9NRF9 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
POLE3 Q9NRF9 DRAP1 Homo sapiens Q14919
Y2H Prey Pooling
25416956
Intra
POLE3 Q9NRF9 DRAP1 Homo sapiens Q14919
Y2H Prey Pooling
32296183
Intra
POLE3 Q9NRF9 DRAP1 Homo sapiens Q14919
Anti Tag CoIP
33961781
Intra
POLE3 Q9NRF9 DRAP1 Homo sapiens Q14919
Y2H Array
32296183
Intra
POLE3 Q9NRF9 DR1 Homo sapiens Q01658
Y2H Array
32296183
Intra
POLE3 Q9NRF9 DR1 Homo sapiens Q01658
Y2H Array
31515488
Intra
POLE3 Q9NRF9 DR1 Homo sapiens Q01658
Y2H Prey Pooling
32296183
Intra
POLE3 Q9NRF9 DR1 Homo sapiens Q01658
MAPPIT
32296183
Intra
POLE3 Q9NRF9 POLE4 Homo sapiens Q9NR33
Anti Tag CoIP
10801849
Intra
POLE3 Q9NRF9 POLE4 Homo sapiens Q9NR33
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Van Esch-O'Driscoll Syndrome

  • X-Linked Intellectual Disability, Van Esch Type

  • VEODS

  • Mrxsveod

  • Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type

  • X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Macular Degeneration, Age-Related, 2

  • Age Related Macular Degeneration 2

  • ARMD2

  • Macular Degeneration, Senile

  • Maculopathy, Age-Related, 2

  • Macular Degeneration, Age-Related, 2, Susceptibility To

  • Macular Degeneration, Age-Related, Type 2
Heinz Body Anemias

  • Heinz Body Anemia

  • Heinz Body Anemias, Alpha-

  • HEIBAN

  • Anemia, Heinz Body

  • Acquired Heinz Body Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10827 POLE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLE3 VGNC VGNC:64285
Rattus norvegicus POLE3 RGD RGD:1359475
Canis familiaris POLE3 VGNC VGNC:44780
Mus musculus POLE3 MGD MGI:1933378
Bos taurus POLE3 VGNC VGNC:33120
Others POLE3 NCBI