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54108

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16

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13252
    MK-5108
    5+ Cited Publications

    VX-689

    		 Aurora Kinase Autophagy Cancer
    MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC50 value of 0.064 nM.
    MK-5108
  • HY-103002
    SU5408
    5 Publications Verification

    VEGFR2 Kinase Inhibitor I

    		 VEGFR Cardiovascular Disease
    SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM.
    SU5408
  • HY-10457
    Velusetrag

    TD-5108

    		 5-HT Receptor Neurological Disease Metabolic Disease
    Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease .
    Velusetrag
  • HY-157331
    DCZ5418

    		NF-κB Apoptosis Cancer
    DCZ5418 is an inhibitor of TRIP13. DCZ5418 has anti-multiple myeloma activity in vitro and in vivo .
    DCZ5418
  • HY-10457A
    Velusetrag hydrochloride

    TD-5108 hydrochloride

    		 5-HT Receptor Neurological Disease Metabolic Disease
    Velusetrag (TD-5108) hydrochloride is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag hydrochloride exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag hydrochloride can be used for the research of gastrointestinal diseases and Parkinson's disease .
    Velusetrag hydrochloride
  • HY-118992
    Aurodox

    X 5108; Goldinomycin

    		 Antibiotic Bacterial Infection
    Aurodox (X 5108) is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth .
    Aurodox
  • HY-175827
    MK-5108-NH-PEG2-alkyne

    		Aurora Kinase Ligands for Target Protein for PROTAC Cancer
    MK-5108-NH-PEG2-alkyne is a Aurora kinase A (AURKA) inhibitor. MK-5108-NH-PEG2-alkyne can be used for synthesis of PROTAC AURKA degrader 1 (HY-175830) .
    MK-5108-NH-PEG2-alkyne
  • HY-107340
    Diftalone

    Aladione; L 5418

    		 Prostaglandin Receptor Inflammation/Immunology
    Diftalone (Aladione) is an anti-inflammatory agent. Diftalone can be used for research of inflammatory disease, such as rheumatoid arthritis .
    Diftalone
  • HY-R03254
    mmu-miR-5108 mimic

    		MicroRNA Cancer
    mmu-miR-5108 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-5108 mimic
    mmu-miR-5108 mimic
  • HY-123639
    LM-4108

    N-(2-Phenylethyl)-indomethacin amide

    		 COX Inflammation/Immunology Cancer
    LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively .
    LM-4108
  • HY-RI03254A
    mmu-miR-5108 antagomir

    		MicroRNA Cancer
    mmu-miR-5108 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5108 antagomir
    mmu-miR-5108 antagomir
  • HY-RI03254
    mmu-miR-5108 inhibitor

    		MicroRNA Cancer
    mmu-miR-5108 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-5108 inhibitor
    mmu-miR-5108 inhibitor
  • HY-R03254A
    mmu-miR-5108 agomir

    		MicroRNA Cancer
    mmu-miR-5108 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5108 agomir
    mmu-miR-5108 agomir
  • HY-10457R
    Velusetrag (Standard)

    TD-5108 (Standard)

    		 Reference Standards 5-HT Receptor Neurological Disease Metabolic Disease
    Velusetrag (Standard) is the analytical standard of Velusetrag (HY-10457). This product is intended for research and analytical applications. Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease .
    Velusetrag (Standard)
  • HY-10457AR
    Velusetrag hydrochloride (Standard)

    TD-5108 hydrochloride (Standard)

    		 Reference Standards 5-HT Receptor Neurological Disease Metabolic Disease
    Velusetrag hydrochloride (Standard) is the analytical standard of Velusetrag hydrochloride (HY-10457A). This product is intended for research and analytical applications. Velusetrag (TD-5108) hydrochloride is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag hydrochloride exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag hydrochloride can be used for the research of gastrointestinal diseases and Parkinson's disease .
    Velusetrag hydrochloride (Standard)
  • HY-103002R
    SU5408 (Standard)

    VEGFR2 Kinase Inhibitor I (Standard)

    		 Reference Standards VEGFR Cardiovascular Disease
    SU5408 (Standard) is the analytical standard of SU5408 (HY-103002). This product is intended for research and analytical applications. SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM.
    SU5408 (Standard)

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