261766-32-9
Chemical Structure
LM-4108
Synonym(s): N-(2-Phenylethyl)-indomethacin amide
- CAS 番号: 261766-32-9
- Formula:C27H25ClN2O3
- Molecular Weight:460.95
IUPAC Name: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethylacetamide
InChIKey: VYDBTNADENXYSN-UHFFFAOYSA-N
SMILES: O=C(N1C2=C(C(CC(NCCC3=CC=CC=C3)=O)=C1C)C=C(OC)C=C2)C4=CC=C(C=C4)Cl
Biological Activity: LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
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LM-4108 | LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively. | |||||||||||||||||||||
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Keywords
