2421187-79-1
Chemical Structure
DiAzKs hydrochloride
Synonym(s): H-L-Photo-lysine hydrochloride
- CAS No.: 2421187-79-1
- Formula:C11H21ClN4O4
- Molecular Weight:308.76
IUPAC Name: N6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonyl)-L-lysine hydrochloride
InChIKey: NFYRMQZAZIBQET-QRPNPIFTSA-N
SMILES: N[C@@H](CCCCNC(OCCC1(C)N=N1)=O)C(O)=O.[H]Cl
Biological Activity: DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe[1][2][3].
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DiAzKs hydrochloride | 98.0% | DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe. | ||||||||||||||||||||
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- [1]. Ai HW, et al. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem. 2011 Aug 16;12(12):1854-7. [Content Brief]
- [2]. Chatterjee A, et al. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11803-8. [Content Brief]
- [3]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2. [Content Brief]
Keywords
