330951-01-4
330951-01-4
Chemical Structure
PRMT5-IN-30
- CAS No.: 330951-01-4
- Formula:C18H17N3O4S
- Molecular Weight:371.41
IUPAC Name: methyl 2-(2-((6-methoxy-1H-benzo[d]imidazol-2-yl)thio)acetamido)benzoate
InChIKey: GZBULYAKSCNNPA-UHFFFAOYSA-N
SMILES: C1(SCC(=O)NC2C=CC=CC=2C(OC)=O)NC2C(=CC=C(OC)C=2)N=1
Biological Activity: PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation[1].
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PRMT5-IN-30 | 99.35% | PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation. | ||||||||||||||||||||
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References
Keywords
