79-17-4
79-17-4
Chemical Structure
Aminoguanidine
Synonym(s): Pimagedine; GER-11free base ; Aminoguanidinium
- CAS No.: 79-17-4
- Formula:CH6N4
- Molecular Weight:74.09
IUPAC Name: hydrazinecarboximidamide
InChIKey: HAMNKKUPIHEESI-UHFFFAOYSA-N
SMILES: N=C(NN)N
Biological Activity: Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research[1][2][3][4].
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Aminoguanidine | Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research. | |||||||||||||||||||||
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Aminoguanidine-13C,15N4 sulfate (1:2) | 99.0% | Aminoguanidine-13C,15N4 sulfate (1:2) is the 13C, 15N labeled Aminoguanidine sulfate (1:2). | ||||||||||||||||||||
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References
- [1]. Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35. [Content Brief]
- [2]. Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484. [Content Brief]
- [3]. Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70. [Content Brief]
- [4]. Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. [Content Brief]
