82-02-0
82-02-0
Chemical Structure
Khellin
- CAS No.: 82-02-0
- Formula:C14H12O5
- Molecular Weight:260.24
IUPAC Name: 4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
InChIKey: HSMPDPBYAYSOBC-UHFFFAOYSA-N
SMILES: O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
Biological Activity: Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].
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Khellin | 99.66% | Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects. | ||||||||||||||||||||
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Khellin (Standard) | ≥98% | Khellin (Standard) is the analytical standard of Khellin. This product is intended for research and analytical applications. Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects. | ||||||||||||||||||||
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References
- [1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81. [Content Brief]
- [2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41. [Content Brief]
Keywords
