82-76-8
Chemical Structure
ANS
Synonym(s): ANSA; 8-Anilino-1-naphthalenesulfonic acid
- CAS No.: 82-76-8
- Formula:C16H13NO3S
- Molecular Weight:299.35
IUPAC Name: 8-(phenylamino)naphthalene-1-sulfonic acid
InChIKey: FWEOQOXTVHGIFQ-UHFFFAOYSA-N
SMILES: O=S(O)(C1=CC=CC2=CC=CC(NC3=CC=CC=C3)=C21)=O
Biological Activity: ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09×106 M-1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development[1][2].
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ANS | 98.01% | ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09×106 M-1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development. | ||||||||||||||||||||
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- [1]. Polak J, et al. Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid. Molecules. 2022 Jan 13;27(2):487. [Content Brief]
- [2]. Brown ML, et al. Use of 8-anilino-1-naphthalenesulfonic acid in radioimmunoassay of triiodothyronine. J Pharm Sci. 1974 Aug;63(8):1214-7. [Content Brief]
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