915360-05-3
915360-05-3
Chemical Structure
Indimitecan
Synonym(s): LMP776
- CAS No.: 915360-05-3
- Formula:C25H21N3O6
- Molecular Weight:459.45
IUPAC Name: 6-(3-(1H-imidazol-1-yl)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
InChIKey: GCILEJUNEYIABW-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6C=NC=C6
Biological Activity: Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].
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Indimitecan | 98.30% | Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. | ||||||||||||||||||||
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References
- [1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. [Content Brief]
Keywords
