Xrcc4 - X-ray repair complementing defective repair in Chinese hamster cells 4 Gene

Also Known as 2310057B22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108138

Summary

Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; and telomeric DNA-containing double minutes formation. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and nervous system development. Located in chromosome, telomeric region. Part of DNA-dependent protein kinase-DNA Ligase 4 complex and ERCC4-ERCC1 complex. Is expressed in head; heart; and trunk. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc4 Products (1)

mRNA Protein Name
NM_028012.4 NP_082288.1 DNA repair protein XRCC4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity IMP
IMP: Inferred from mutant phenotype
14690602 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within DN2 thymocyte differentiation IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within DNA ligation IDA
IDA: Inferred from direct assay
15194694 MGI
acts upstream of or within V(D)J recombination IMP
IMP: Inferred from mutant phenotype
10716994 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
17713479 MGI
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
14690602 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within immunoglobulin V(D)J recombination IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within isotype switching IMP
IMP: Inferred from mutant phenotype
17713479 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9875844 MGI
involved in negative regulation of protection from non-homologous end joining at telomere IMP
IMP: Inferred from mutant phenotype
14690602 MGI
acts upstream of neurogenesis IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within pro-B cell differentiation IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
17713479 MGI
involved in telomeric DNA-containing double minutes formation IMP
IMP: Inferred from mutant phenotype
14690602 MGI
Cellular Component GO Annotation Evidence Références Source
part of DNA-dependent protein kinase-DNA ligase 4 complex IDA
IDA: Inferred from direct assay
15194694 MGI
part of ERCC4-ERCC1 complex IDA
IDA: Inferred from direct assay
14690602 MGI
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
14690602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein XRCC4

  • X-ray repair cross-complementing protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15899 XRCC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118273 IPS-05002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrcc4 NCBI NCBI:7518