TAFA4 - TAFA chemokine like family member 4 Gene

Also Known as TAFA-4; FAM19A4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151647

About TAFA4

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:68,731,766-68,932,547 (from NCBI)

This gene has 3 transcripts (splice variants), 181 orthologues and 3 paralogues. Biased expression in adrenal (RPKM 8.7), gall bladder (RPKM 0.7) and 1 other tissue.

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

TAFA4 Products (2)

mRNA	Protein	Name
NM_001005527.3	NP_001005527.1	chemokine-like protein TAFA-4 precursor
NM_182522.5	NP_872328.1	chemokine-like protein TAFA-4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in extracellular space	IDA IDA: Inferred from direct assay	29453251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAFA4 Protein Structure

TAFA

0
100
140 a.a.

Protein Preferred Names	Protein Names
chemokine-like protein TAFA-4	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

TAFA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TAFA4	Q96LR4	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAFA4 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71350	TAFA4 Protein, Human (His)	Q96LR4 (S35-R140)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Xiii	Osteogenesis Imperfecta Type 13 OI13 Osteogenesis Imperfecta Type Xiii Oi, Type Xiii Osteogenesis Imperfecta 13 Oi Type Xiii Oi-Xiii
Inflammatory Bowel Disease 9	IBD9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14182	TAFA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18550	Tafa4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25032	Tafa4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAFA4	VGNC	VGNC:78191
Mus musculus	TAFA4	MGD	MGI:2444563
Canis familiaris	TAFA4	VGNC	VGNC:40648
Rattus norvegicus	TAFA4	RGD	RGD:1597443
Felis catus	TAFA4	VGNC	VGNC:65940
Others	TAFA4	NCBI