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RNF38 - ring finger protein 38 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 152006

About RNF38

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,336,400-36,487,669 (from NCBI)

This gene has 10 transcripts (splice variants), 267 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 25.8), ovary (RPKM 14.9) and 25 other tissues.

Summary

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

RNF38 Products (5)

mRNA	Protein	Name
NM_022781.5	NP_073618.3	E3 ubiquitin-protein ligase RNF38 isoform 1
NM_194328.3	NP_919309.1	E3 ubiquitin-protein ligase RNF38 isoform 2
NM_194329.3	NP_919310.1	E3 ubiquitin-protein ligase RNF38 isoform 3
NM_194330.3	NP_919311.1	E3 ubiquitin-protein ligase RNF38 isoform 2
NM_194332.3	NP_919313.1	E3 ubiquitin-protein ligase RNF38 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23973461	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	23973461	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	23973461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF38 Protein Structure

zf-RING_2

0
100
200
300
400
515 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF38	RING-type E3 ubiquitin transferase RNF38

RNF38 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RNF38	Q9H0F5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	RNF38	Q9H0F5	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Array	32296183
Intra	RNF38	Q9H0F5	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RNF38	Q9H0F5	RNF208	Homo sapiens	Q9H0X6	Validated Y2H	32296183
Intra	RNF38	Q9H0F5	RNF208	Homo sapiens	Q9H0X6	Y2H Array	32296183
Intra	RNF38	Q9H0F5	RNF208	Homo sapiens	Q9H0X6	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	RNF38	Q9H0F5	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colon Mucinous Adenocarcinoma	Colonic Mucinous Adenocarcinoma Mucinous Adenocarcinoma Of The Colon
Uterine Corpus Endometrial Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12088	RNF38 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF38	VGNC	VGNC:34064
Mus musculus	RNF38	MGD	MGI:1920719
Felis catus	RNF38	VGNC	VGNC:64701
Macaca mulatta	RNF38	VGNC	VGNC:76761
Rattus norvegicus	RNF38	RGD	RGD:621856
Canis familiaris	RNF38	VGNC	VGNC:45668
Others	RNF38	NCBI