GRB10 - growth factor receptor bound protein 10 Gene

Also Known as RSS; IRBP; MEG1; GRB-IR; Grb-10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2887

About GRB10

Cytogenetic location: 7p12.1 Genomic coordinates (GRCh38): 7:50,590,068-50,793,453 (from NCBI)

This gene has 26 transcripts (splice variants), 280 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues.

Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with Insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GRB10 Products (8)

mRNA	Protein	Name
NM_001001549.3	NP_001001549.1	growth factor receptor-bound protein 10 isoform b
NM_001001550.3	NP_001001550.1	growth factor receptor-bound protein 10 isoform c
NM_001001555.3	NP_001001555.1	growth factor receptor-bound protein 10 isoform c
NM_001350814.2	NP_001337743.1	growth factor receptor-bound protein 10 isoform a
NM_001350815.2	NP_001337744.1	growth factor receptor-bound protein 10 isoform d
NM_001350816.3	NP_001337745.2	growth factor receptor-bound protein 10 isoform c
NM_001371008.1	NP_001357937.1	growth factor receptor-bound protein 10 isoform c
NM_001371009.1	NP_001357938.1	growth factor receptor-bound protein 10 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19648926	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8798570	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	17376403	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15060076	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	20878056	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB10 Protein Structure

RA

PH

BPS

SH2

0
100
200
300
400
500
594 a.a.

Protein Preferred Names	Protein Names
growth factor receptor-bound protein 10	GRB10 adapter protein

GRB10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	GRB10	Q13322	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	GRB10	Q13322	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Anti Bait CoIP	23246379
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Pull Down	23246379
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Anti Tag CoIP	23246379
Intra	GRB10	Q13322	INSR	Homo sapiens	P06213	Pull Down	9506989
Intra	GRB10	Q13322	INSR	Homo sapiens	P06213	Protein 3 Hybrid	9506989
Intra	GRB10	Q13322	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	GRB10	Q13322	EPHB1	Homo sapiens	P54762	Pull Down	8798570
Intra	GRB10	Q13322	RCAN3	Homo sapiens	Q9UKA8	Validated Y2H	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Transient Neonatal Diabetes Mellitus	Diabetes Mellitus, Transient Neonatal Tndm Chromosome 6-Associated Transient Diabetes Mellitus Dmtn Diabetes Mellitus, 6q24-Related Transient Neonatal Tndm1 Neonatal Diabetes Mellitus, Transient Tndm -[Transient Neonatal Diabetes Mellitus]
Silver-Russell Syndrome 1	Silver-Russell Syndrome Russell-Silver Syndrome Silver-Russell Dwarfism Rss SRS1 Srs Silver Russell Dwarfism Russell Silver Syndrome Silver Russell Syndrome
Spastic Paraplegia 17, Autosomal Dominant	Silver Syndrome SPG17 Silver Spastic Paraplegia Syndrome Spastic Paraplegia With Amyotrophy Of Hands And Feet Hereditary Spastic Paraplegia 17 Autosomal Dominant Spastic Paraplegia Type 17 Spastic Paraplegia 17 Spastic Paraplegia-Amyotrophy Of Hands And Feet Autosomal Dominant Spastic Paraplegia 17 Dhmn5b Distal Hereditary Motor Neuropathy Type 5b Paraplegia, Spastic, Autosomal Dominant, Type 17 Russell-Silver Syndrome Neuronopathy, Distal Hereditary Motor, Type Vb
Mulchandani-Bhoj-Conlin Syndrome	MBCS Maternal Uniparental Disomy Of Chromosome 20 Maternal Upd(20) Upd(20)Mat Uniparental Disomy, Maternal, Chromosome 20
Temple Syndrome	Uniparental Disomy, Maternal, Chromosome 14 Temple Syndrome Due To Paternal 14q32.2 Microdeletion Paternal Del(14)(Q32.2) Temple Syndrome Due To Paternal 14q32.2 Hypomethylation Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14 Upd(14)Mat
Isolated Growth Hormone Deficiency, Type Ib	Isolated Growth Hormone Deficiency Type Ib IGHD1B Ighd Ib Growth Hormone Deficiency, Isolated, Type Ib Congenital Ighd Type Ib Congenital Isolated Gh Deficiency Type Ib Congenital Isolated Growth Hormone Deficiency Type Ib Dwarfism Of Sindh Pituitary Dwarfism I Isolated Growth Hormone Deficiency Type 1b Ighd 1b Growth Hormone Deficiency, Isolated, 1b
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Kagami-Ogata Syndrome	Paternal Uniparental Disomy Of Chromosome 14 Uniparental Disomy, Paternal, Chromosome 14 Kos Mca Due To 14q32.2 Maternally Expressed Gene Defect Paternal Uniparental Disomy 14 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion Maternal Del(14)(Q32.2) Maternal Monosomy 14q32.2 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14 Upd(14)Pat
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type Iii Oi Type 3 Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05778	GRB10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22539	Grb10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29059	Grb10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRB10	VGNC	VGNC:67456
Bos taurus	GRB10	VGNC	VGNC:29629
Macaca mulatta	GRB10	VGNC	VGNC:73157
Mus musculus	GRB10	MGD	MGI:103232
Canis familiaris	GRB10	VGNC	VGNC:51874
Rattus norvegicus	GRB10	RGD	RGD:1566234
Others	GRB10	NCBI