Vps11 - VPS11 core subunit of CORVET and HOPS complexes Gene

Predicted to enable several functions, including protein-macromolecule adaptor activity; syntaxin binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of intracellular Estrogen receptor signaling pathway; positive regulation of intracellular transport; and vesicle organization. Predicted to act upstream of or within toxin transport. Predicted to be located in actin filament and endocytic vesicle. Predicted to be part of AP-3 adaptor complex; CORVET complex; and HOPS complex. Predicted to be active in endosome and presynaptic active zone. Predicted to colocalize with early endosome; late endosome; and lysosome. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]