VPS11 - VPS11 core subunit of CORVET and HOPS complexes Gene

Also Known as END1; PEP5; HLD12; RNF108; hVPS11; HLD12; DYT32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55823

About VPS11

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,067,818-119,081,972 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 16.0), bone marrow (RPKM 14.4) and 25 other tissues.

Summary

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

VPS11 Products (6)

mRNA Protein Name
NM_001290185.2 NP_001277114.1 vacuolar protein sorting-associated protein 11 homolog isoform 2
NM_001378218.1 NP_001365147.1 vacuolar protein sorting-associated protein 11 homolog isoform 3
NM_001378219.1 NP_001365148.1 vacuolar protein sorting-associated protein 11 homolog isoform 4
NM_001378220.1 NP_001365149.1 vacuolar protein sorting-associated protein 11 homolog isoform 5
NM_001378221.1 NP_001365150.1 vacuolar protein sorting-associated protein 11 homolog isoform 6
NM_021729.6 NP_068375.3 vacuolar protein sorting-associated protein 11 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11382755 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
21148287 GOA
enables syntaxin binding IDA
IDA: Inferred from direct assay
11382755 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
31015428 GOA
Biological Process GO Annotation Evidence References Source
involved in endosomal vesicle fusion IMP
IMP: Inferred from mutant phenotype
21148287 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
25783203 GOA
involved in negative regulation of intracellular estrogen receptor signaling pathway IGI
IGI: Inferred from genetic interaction
31015428 GOA
involved in positive regulation of early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
21148287 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
21148287 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
31015428 GOA
involved in regulation of organelle assembly IMP
IMP: Inferred from mutant phenotype
21148287 GOA
Cellular Component GO Annotation Evidence References Source
part of HOPS complex IDA
IDA: Inferred from direct assay
19109425 GOA
colocalizes with early endosome IDA
IDA: Inferred from direct assay
21148287 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
20682791 GOA
located in endosome IDA
IDA: Inferred from direct assay
20682791 GOA
colocalizes with late endosome IDA
IDA: Inferred from direct assay
21148287 GOA
located in late endosome IDA
IDA: Inferred from direct assay
11382755 GOA
colocalizes with lysosome IDA
IDA: Inferred from direct assay
21148287 GOA
located in lysosome IDA
IDA: Inferred from direct assay
11382755 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS11 Protein Structure

Clathrin

Clathrin: Region in Clathrin and VPS (416 - 535)

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (821 - 859)

VPS11_C

VPS11_C: Vacuolar protein sorting protein 11 C terminal (861 - 908)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 940 a.a.
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 11 homolog

  • RING finger protein 108

VPS11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Anti Tag CoIP
33422265
Intra
VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Y2H
23901104
Intra
VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Bait CoIP
11382755
Intra
VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Y2H
23901104
Intra
VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
28514442
Intra
VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
26496610
Intra
VPS11 Q9H270 VPS41 Homo sapiens P49754
Anti Tag CoIP
33422265
Intra
VPS11 Q9H270 VPS41 Homo sapiens P49754
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 BMI1 Homo sapiens P35226
Anti Tag CoIP
22493164
Intra
VPS11 Q9H270 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
26496610
Intra
VPS11 Q9H270 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Bait CoIP
11382755
Intra
VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
26496610
Intra
VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
33961781
Intra
VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
28514442
Intra
VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
26496610
Intra
VPS11 Q9H270 STX7 Homo sapiens O15400
Anti Tag CoIP
11382755
Intra
VPS11 Q9H270 STX7 Homo sapiens O15400
Anti Bait CoIP
11382755
Intra
VPS11 Q9H270 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
VPS11 Q9H270 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
VPS11 Q9H270 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
VPS11 Q9H270 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
VPS11 Q9H270 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
VPS11 Q9H270 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
VPS11 Q9H270 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
VPS11 Q9H270 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
VPS11 Q9H270 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
VPS11 Q9H270 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
VPS11 Q9H270 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
VPS11 Q9H270 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Cross
VPS11 Q9H270 Vps33a Rattus norvegicus Q63615
Anti Bait CoIP
11382755
Cross
VPS11 Q9H270 Vps33a Rattus norvegicus Q63615
Anti Tag CoIP
11382755
Cross: Cross-species interaction Intra: Intraspecies interaction

VPS11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82692 VPS11 Antibody (YA2437) WB, IHC-P, FC Human, Mouse

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 12

  • Hypomyelinating Leukodystrophy 12

  • HLD12

  • Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy

  • Vps11-Related Autosomal Recessive Hypomyelinating Leukoencephalopathy
Dystonia 32

  • DYT32
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Chronic Apical Periodontitis

  • Apical Periodontitis Nos

  • Apex Periodontitis

  • Periapical Infection Nos
Leukodystrophy

  • Leukodystrophies
Visual Cortex Disease

  • Visual Cortex Dysfunction

  • Visual Cortex Disorder

  • Visual Cortical Disorder

  • Disease Of Visual Cortex
Visual Pathway Disease

  • Disorder Of Visual Pathways
Hypomyelinating Leukodystrophy

  • Hld

  • Leukodystrophy, Hypomyelinating
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15671 VPS11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus VPS11 RGD RGD:1308038
Mus musculus VPS11 MGD MGI:1918982
Macaca mulatta VPS11 VGNC VGNC:78965
Bos taurus VPS11 VGNC VGNC:36809
Canis familiaris VPS11 VGNC VGNC:48273
Felis catus VPS11 VGNC VGNC:66953
Others VPS11 NCBI