VPS11 Antibody (YA2437)

Cat. No.: HY-P82692: Data Sheet COA
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VPS11 Antibody (YA2437) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VPS11.

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사이즈	재고	수량
20 μL	해외재고보유	Estimated Time of Arrival: December 31
50 μL	해외재고보유	Estimated Time of Arrival: December 31
100 μL	해외재고보유	Estimated Time of Arrival: December 31
250 μL	견적 받기

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VPS11 Antibody (YA2437) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

VPS11 Antibody (YA2437) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VPS11.

Host

Rabbit

Clonality

Recombinant,Monoclonal

분자량

Predicted band size: 108 kDa;

Observed band size: 108 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q9H270

Gene ID

55823 [NCBI]

Immunogen

A synthesized peptide derived from human VPS11 aa10-44.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995)

Subcellular Localization：Endosome; Late endosome membrane; Peripheral membrane protein; Cytoplasmic side; Lysosome membrane; Peripheral membrane protein; Cytoplasmic side; Early endosome; Cytoplasmic vesicle; Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle, clathrin-coated vesicle

Expression：
Tissue_specificity:Ubiquitous. Expression was highest in heart and low in lung

Subunit：Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:11382755, PubMed:20434987, PubMed:23351085, PubMed:23901104, PubMed:25266290, PubMed:25783203). Interacts with TGFBRAP1, MON1B, STX7, STX17, EZR, RDX, MSN, ECPAS (PubMed:11382755, PubMed:20682791, PubMed:21148287, PubMed:24554770, PubMed:25266290). Interacts with RAB5C (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity). Interacts with PLEKHM1 (PubMed:28325809)

Database

Entrez Gene: 55823 Human ; 71732 Mouse ;

SwissProt: Q9H270 Human ; Q91W86 Mouse ;

OMIM: 616683 Human

Research Field

Signal Transduction

Synonyms

END1; hVPS11; PEP5; PP3476; RNF108; vps11

각종 서류

Select Batch:

Data Sheet (234 KB) SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

VPS11 Antibody (YA2437) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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VPS11 Antibody (YA2437)

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Product Detail

Background

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VPS11 Antibody (YA2437) Related Classifications

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