VPS18 - VPS18 core subunit of CORVET and HOPS complexes Gene

Also Known as PEP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57617

About VPS18

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,894,450-40,903,975 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

Summary

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]

VPS18 Products (1)

mRNA	Protein	Name
NM_020857.3	NP_065908.1	vacuolar protein sorting-associated protein 18 homolog

VPS18 Protein Structure

Pep3_Vps18

Clathrin

0
200
400
600
800
973 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 18 homolog	VPS18, CORVET/HOPS core subunit

VPS18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS18	Q9P253	VPS39	Homo sapiens	Q96JC1	Anti Tag CoIP	33422265
Intra	VPS18	Q9P253	VPS41	Homo sapiens	P49754	Y2H	23901104
Intra	VPS18	Q9P253	VPS41	Homo sapiens	P49754	Anti Tag CoIP	33422265
Intra	VPS18	Q9P253	VPS41	Homo sapiens	P49754	Anti Tag CoIP	26496610
Intra	VPS18	Q9P253	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	26496610
Intra	VPS18	Q9P253	VPS33A	Homo sapiens	Q96AX1	Anti Bait CoIP	25783203
Intra	VPS18	Q9P253	MON1B	Homo sapiens	Q7L1V2	Y2H	20434987
Intra	VPS18	Q9P253	MON1B	Homo sapiens	Q7L1V2	Pull Down	20434987
Intra	VPS18	Q9P253	VPS16	Homo sapiens	Q9H269	Anti Bait CoIP	25783203
Intra	VPS18	Q9P253	VPS16	Homo sapiens	Q9H269	Anti Bait CoIP	11382755
Intra	VPS18	Q9P253	VPS16	Homo sapiens	Q9H269	Anti Tag CoIP	26496610
Intra	VPS18	Q9P253	VPS11	Homo sapiens	Q9H270	Anti Bait CoIP	11382755
Intra	VPS18	Q9P253	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	26496610
Cross	VPS18	Q9P253	Vps33a	Rattus norvegicus	Q63615	Anti Tag CoIP	11382755

Cross: Cross-species interaction Intra: Intraspecies interaction

VPS18 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82700	VPS18 Antibody (YA2445)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15677	VPS18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21082	Vps18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27599	Vps18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VPS18	RGD	RGD:1311556
Canis familiaris	VPS18	VGNC	VGNC:48279
Mus musculus	VPS18	MGD	MGI:2443626
Felis catus	VPS18	VGNC	VGNC:66959
Macaca mulatta	VPS18	VGNC	VGNC:78999
Bos taurus	VPS18	VGNC	VGNC:36812
Others	VPS18	NCBI