TGFBRAP1 - transforming growth factor beta receptor associated protein 1 Gene

Homo sapiens

Also known as VPS3; TRAP1; TRAP-1

Gene ID: 9392 | Gene type: protein coding

About TGFBRAP1

Cytogenetic location: 2q12.1-q12.2 Genomic coordinates (GRCh38): 2:105,249,404-105,329,735 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.3), thyroid (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

TGFBRAP1 Products(3)

mRNA	Protein	Name
NM_001142621.3	NP_001136093.1	transforming growth factor-beta receptor-associated protein 1 isoform 1
NM_001328646.3	NP_001315575.1	transforming growth factor-beta receptor-associated protein 1 isoform 2
NM_004257.6	NP_004248.2	transforming growth factor-beta receptor-associated protein 1 isoform 1

TGFBRAP1 Protein Structure

CNH

Vps39_1

Clathrin

Vps39_2

0
200
400
600
800
860 a.a.

Protein Preferred Names

Protein Names

transforming growth factor-beta receptor-associated protein 1

TGF-beta receptor-associated protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14454	TGFBRAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TGFBRAP1	VGNC	VGNC:35806
Canis familiaris	TGFBRAP1	VGNC	VGNC:47313
Rattus norvegicus	TGFBRAP1	RGD	RGD:1310772
Felis catus	TGFBRAP1	VGNC	VGNC:66138
Mus musculus	TGFBRAP1	MGD	MGI:2447427
Macaca mulatta	TGFBRAP1	VGNC	VGNC:78396

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