TGFBRAP1 - transforming growth factor beta receptor associated protein 1 Gene

Also Known as VPS3; TRAP1; TRAP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9392

About TGFBRAP1

Cytogenetic location: 2q12.1-q12.2 Genomic coordinates (GRCh38): 2:105,249,404-105,329,735 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.3), thyroid (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

TGFBRAP1 Products (3)

mRNA	Protein	Name
NM_001142621.3	NP_001136093.1	transforming growth factor-beta receptor-associated protein 1 isoform 1
NM_001328646.3	NP_001315575.1	transforming growth factor-beta receptor-associated protein 1 isoform 2
NM_004257.6	NP_004248.2	transforming growth factor-beta receptor-associated protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IDA IDA: Inferred from direct assay	11278302	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278302	GOA
enables transforming growth factor beta receptor binding	IDA IDA: Inferred from direct assay	11278302	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosomal vesicle fusion	IMP IMP: Inferred from mutant phenotype	25266290	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	25266290	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11278302	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	11278302	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	25266290	GOA
located in membrane	IDA IDA: Inferred from direct assay	11278302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBRAP1 Protein Structure

CNH

Vps39_1

Clathrin

Vps39_2

0
200
400
600
800
860 a.a.

Protein Preferred Names	Protein Names
transforming growth factor-beta receptor-associated protein 1	TGF-beta receptor-associated protein 1

TGFBRAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TGFBRAP1	Q8WUH2	VPS16	Homo sapiens	Q9H269	Anti Bait CoIP	25266290
Intra	TGFBRAP1	Q8WUH2	VPS16	Homo sapiens	Q9H269	Anti Tag CoIP	35271311
Intra	TGFBRAP1	Q8WUH2	VPS16	Homo sapiens	Q9H269	Anti Tag CoIP	33961781
Intra	TGFBRAP1	Q8WUH2	VPS11	Homo sapiens	Q9H270	Anti Bait CoIP	25266290
Intra	TGFBRAP1	Q8WUH2	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	35271311
Intra	TGFBRAP1	Q8WUH2	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	33961781
Intra	TGFBRAP1	Q8WUH2	VPS8	Homo sapiens	Q8N3P4	Anti Tag CoIP	33961781
Intra	TGFBRAP1	Q8WUH2	VPS8	Homo sapiens	Q8N3P4	Anti Bait CoIP	25266290

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14454	TGFBRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TGFBRAP1	VGNC	VGNC:35806
Canis familiaris	TGFBRAP1	VGNC	VGNC:47313
Rattus norvegicus	TGFBRAP1	RGD	RGD:1310772
Felis catus	TGFBRAP1	VGNC	VGNC:66138
Mus musculus	TGFBRAP1	MGD	MGI:2447427
Macaca mulatta	TGFBRAP1	VGNC	VGNC:78396
Others	TGFBRAP1	NCBI