VPS8 - VPS8 subunit of CORVET complex Gene

Also Known as KIAA0804

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23355

About VPS8

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:184,812,166-185,052,614 (from NCBI)

This gene has 28 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 8.2), brain (RPKM 7.7) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Apr 2022]

VPS8 Products (9)

mRNA	Protein	Name
NM_001009921.3	NP_001009921.1	vacuolar protein sorting-associated protein 8 homolog isoform a
NM_001349292.2	NP_001336221.1	vacuolar protein sorting-associated protein 8 homolog isoform a
NM_001349293.2	NP_001336222.1	vacuolar protein sorting-associated protein 8 homolog isoform a
NM_001349294.2	NP_001336223.1	vacuolar protein sorting-associated protein 8 homolog isoform a
NM_001349295.1	NP_001336224.1	vacuolar protein sorting-associated protein 8 homolog isoform a
NM_001349296.2	NP_001336225.1	vacuolar protein sorting-associated protein 8 homolog isoform c
NM_001349297.2	NP_001336226.1	vacuolar protein sorting-associated protein 8 homolog isoform d
NM_001349298.2	NP_001336227.1	vacuolar protein sorting-associated protein 8 homolog isoform e
NM_015303.4	NP_056118.2	vacuolar protein sorting-associated protein 8 homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25266290	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosomal vesicle fusion	IMP IMP: Inferred from mutant phenotype	25266290	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	25266290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS8 Protein Structure

Vps8

0
300
600
900
1200
1428 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 8 homolog	VPS8, CORVET complex subunit

VPS8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS8	Q8N3P4	TGFBRAP1	Homo sapiens	Q8WUH2	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ritscher-Schinzel Syndrome 1	3c Syndrome Craniocerebellocardiac Dysplasia RTSC1 Dandy-Walker-Like Malformation With Atrioventricular Septal Defect Dandy-Walker Like Malformation With Atrioventricular Septal Defect Cranio-Cerebello-Cardiac Dysplasia Dandy-Walker-Like Malformation With Asd Ritscher Schinzel Syndrome Ritscher-Schinzel Cranio-Cerebello-Cardiac Syndrome Ritscher-Schinzel Syndrome 3c
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15701	VPS8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VPS8	RGD	RGD:1309443
Felis catus	VPS8	VGNC	VGNC:97683
Macaca mulatta	VPS8	VGNC	VGNC:79779
Mus musculus	VPS8	MGD	MGI:2146407
Bos taurus	VPS8	VGNC	VGNC:36832
Canis familiaris	VPS8	VGNC	VGNC:48300