DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

  • Nat Prod Res. 2005 Jul;19(5):457-60. doi: 10.1080/14786410412331272095.
Ahmet C Gören  1 ,  Bing-Nan Zhou ,  Gülaçti Topçu ,  Gamze Kökdil ,  David G I Kingston
Affiliations
  • 1. TUBITAK, Ulusal Metroloji Enstitüsü, Group of Chemistry, PO Box 54, 41470, Gebze-Kocaeli, Turkey. [email protected]
PMID: 15938192 DOI: 10.1080/14786410412331272095
Abstract

An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.

Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-W750451
    Reptoside
    99.92%, DNA Damaging Activator
    target: Akt
    Research Areas: Cancer