Stellettins L and M, cytotoxic isomalabaricane-type triterpenes, and sterols from the marine sponge Stelletta tenuis

  • J Nat Prod. 2007 Jul;70(7):1114-7. doi: 10.1021/np070069l.
Hou-wen Lin  1 ,  Zeng-lei Wang ,  Jiu-hong Wu ,  Ning Shi ,  Hong-jun Zhang ,  Wan-sheng Chen ,  Susan L Morris-Natschke ,  An-Shen Lin
Affiliations
  • 1. Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, People's Republic of China.
PMID: 17604394 DOI: 10.1021/np070069l
Abstract

Two new isomalabaricane-type Triterpenes, stellettins L (1) and M (2), and three new sterols (3-5) were isolated from the marine Sponge Stelletta tenuis collected in the South China Sea. Chemical structures were established from spectroscopic data and comparison with known compounds. In addition, spectroscopic data reported for the known sterol 24-methylene-27-methylcholest-5-en-3beta-ol-7-one (6) were revised. Compounds 1 and 2 exhibited significant cytotoxic activity against stomach Cancer (AGS) in vitro.