A brief overview on recent advances in spiro[chromane-2,4'-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

  • Bioorg Med Chem. 2020 Dec 1;28(23):115813. doi: 10.1016/j.bmc.2020.115813.
Nitin G Ghatpande  1 ,  Jagannath S Jadhav  2 ,  Rajshekhar V Kaproormath  3 ,  Mahmoud E Soliman  4 ,  Mahidansha M Shaikh  5
Affiliations
  • 1. Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa; Unique Med Chem Laboratories, L-64, Chincholli MIDC, Solapur 413255, M.S., India.
  • 2. Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India.
  • 3. Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa. Electronic address: [email protected].
  • 4. Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa.
  • 5. Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa; Unique Med Chem Laboratories, L-64, Chincholli MIDC, Solapur 413255, M.S., India. Electronic address: [email protected].
PMID: 33069128 DOI: 10.1016/j.bmc.2020.115813
Abstract

The spiro[chromane-2,4'-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4'-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4'-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.

Keywords
4′-piperidine]-4(3H)-one; Biological activity; Pharmacophores; Spiro[chromane-2; structure activity relationship (SAR).