1461717-05-4
Chemical Structure
Aftin-5
- CAS. Nr.: 1461717-05-4
- Formula:C19H26N6O
- Molecular Weight:354.45
IUPAC Name: (R)-2-((9-isopropyl-6-(methyl(phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol
InChIKey: HYFZLABHJHEEFS-CQSZACIVSA-N
SMILES: CC[C@H](CO)NC1=NC(N(C2=CC=CC=C2)C)=C3N=CN(C3=N1)C(C)C
Biological Activity: Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively[1].
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Aftin-5 | 99.70% | Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively. | ||||||||||||||||||||
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Keywords
