201215-10-3
Chemical Structure
A-75943
- CAS. Nr.: 201215-10-3
- Formula:C15H23NO4
- Molecular Weight:281.35
IUPAC Name: 2-((2R,4S)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-6-oxotetrahydro-2H-pyran-4-yl)acetamide
InChIKey: SAVFIMRLAWCZGX-UHFZAUJKSA-N
SMILES: O=C1[C@]([C@]2(C[C@@H](CC(N)=O)CC(=O)O2)[H])(C[C@@H](C)C[C@@H]1C)[H]
Biological Activity: A-75943 is a bone resorption inhibitor isolated from Streptomyces sp. SANK 61296, with protein synthesis toxicity. A-75943 inhibits bone resorption in vitro, and also suppresses the increase in serum calcium levels and the decrease in bone mineral density in thyroparathyroidectomized rats. A-75943 inhibits protein synthesis. High concentrations of A-75943 reduce the survival rate of osteoclasts on bone slices, while low concentrations have no effect on the survival rate or morphology of osteoclasts. A-75943 can be used for the research of osteoporosis and hypercalcemia[1].
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A-75943 | A-75943 is a bone resorption inhibitor isolated from Streptomyces sp. SANK 61296, with protein synthesis toxicity. A-75943 inhibits bone resorption in vitro, and also suppresses the increase in serum calcium levels and the decrease in bone mineral density in thyroparathyroidectomized rats. A-75943 inhibits protein synthesis. High concentrations of A-75943 reduce the survival rate of osteoclasts on bone slices, while low concentrations have no effect on the survival rate or morphology of osteoclasts. A-75943 can be used for the research of osteoporosis and hypercalcemia. | |||||||||||||||||||||
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Keywords
