A novel bone resorption inhibitor, A-75943 isolated from Streptomyces sp. SANK 61296

  • J Antibiot (Tokyo). 1998 Jun;51(6):531-8. doi: 10.7164/antibiotics.51.531.
T Morishita  1 ,  A Sato ,  T Ando ,  K Oizumi ,  M Miyamoto ,  R Enokita ,  T Okazaki
Affiliations
  • 1. Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 9711215 DOI: 10.7164/antibiotics.51.531
Abstract

A novel bone resorption inhibitor, A-75943, was isolated from Streptomyces sp. SANK 61296. Its structure was determined to be (1"S,2'R,3"S,4S',5"S)-2-[(3",5"- dimethyl-2"-oxocyclohexan-1"-yl)-6'-oxotetrahydropyran-4'-yl ]acetamide by spectral analyses and chemical conversion of cycloheximide. A-75943 inhibited bone resorption in vitro in a concentration-dependent manner with an IC50 of 0.35 microM, and also displayed an inhibitory effect on bone resorption in thyroid and parathyroid-extracted rats.

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