2429876-60-6
2429876-60-6
Chemical Structure
PPI stabilizer-1
- CAS. Nr.: 2429876-60-6
- Formula:C40H40N6O4
- Molecular Weight:668.78
InChIKey: LWNXLGGZVHNJBW-UWXQCODUSA-N
SMILES: O=C(N1)C(C([C@H]1C(C2=CC=CC=C2N3)=C3CNCCCCCCNCC4=C([C@@H]5C6=CC(O)=CC=C6C(N5)=O)C7=CC=CC=C7N4)=C8)=CC=C8O
Biological Activity: PPI stabilizer-1-1 (Compound 2) is a KRAS dimerizing agent. PPI stabilizer-1-1 dimerizes KRAS with a KD of 3.8 µM. PPI stabilizer-1-1 co-crystallizes with GCP-KRASG12D. PPI stabilizer-1 can be used for the research of KRAS-driven cancers[1].
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PPI stabilizer-1 | PPI stabilizer-1-1 (Compound 2) is a KRAS dimerizing agent. PPI stabilizer-1-1 dimerizes KRAS with a KD of 3.8 µM. PPI stabilizer-1-1 co-crystallizes with GCP-KRASG12D. PPI stabilizer-1 can be used for the research of KRAS-driven cancers. | |||||||||||||||||||||
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References
Keywords
