85118-43-0
85118-43-0
Chemical Structure
Fluprofylline
Synonym(s): Sgd 144/8
- CAS. Nr.: 85118-43-0
- Formula:C22H26FN5O3
- Molecular Weight:427.47
InChIKey: IPSYNNODBHPDFB-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1C)=O)N=CN2CCCN3CCC(CC3)C(C4=CC=C(C=C4)F)=O
Biological Activity: Fluprofylline (Sgd 144/8) is a selective α1-adrenergic receptor antagonist with a pIC50 of 7.55. Fluprofylline attenuates the pressor response induced by 5-HT (HY-B1473A). Fluprofylline can be used in hypertension research[1].
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Fluprofylline | Fluprofylline (Sgd 144/8) is a selective α1-adrenergic receptor antagonist with a pIC50 of 7.55. Fluprofylline attenuates the pressor response induced by 5-HT (HY-B1473A). Fluprofylline can be used in hypertension research. | |||||||||||||||||||||
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References
- [1]. Korstanje C, et al. Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin. J Pharm Pharmacol. 1986 May;38(5):374-9. [Content Brief]
Keywords
