Pld4 - phospholipase D family, member 4 Gene

Also Known as thss

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104759

Summary

Enables single-stranded DNA 5'-3' exodeoxyribonuclease activity. Involved in regulation of cytokine production involved in inflammatory response. Acts upstream of or within hematopoietic progenitor cell differentiation and phagocytosis. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain and hemolymphoid system. Used to study systemic lupus erythematosus. Orthologous to human PLD4 (Phospholipase D family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Pld4 Products (1)

mRNA Protein Name
NM_178911.4 NP_849242.1 5'-3' exonuclease PLD4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables phospholipase D activity IDA
IDA: Inferred from direct assay
21085684 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18706977 MGI
enables single-stranded DNA 5'-3' DNA exonuclease activity IMP
IMP: Inferred from mutant phenotype
22102906 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
22102906 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
22102906 MGI
involved in regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
22102906 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
22102906 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21085684 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21085684 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22102906 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
22102906 MGI
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
21085684 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exonuclease PLD4

  • PLD 4

  • choline phosphatase 4

  • phosphatidylcholine-hydrolyzing phospholipase D4

  • phospholipase D4

Recombinant Pld4 Proteins

Cat. No. Product Name Accession Purity
HY-P77821 PLD4 Protein, Mouse (HEK293, His) Q8BG07-1 (Q58-W503) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10673 PLD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18149 Pld4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24624 Pld4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pld4 NCBI NCBI:122618