PLD4 - phospholipase D family member 4 Gene

Also Known as C14orf175

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 122618

About PLD4

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,924,879-104,937,785 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in skin (RPKM 31.7), spleen (RPKM 4.6) and 9 other tissues.

Summary

Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLD4 Products (2)

mRNA Protein Name
NM_001308174.2 NP_001295103.1 5'-3' exonuclease PLD4 isoform 1
NM_138790.5 NP_620145.2 5'-3' exonuclease PLD4 isoform 2

PLD4 Protein Structure

PLDc_3

PLDc_3: PLD-like domain (236 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
Protein Preferred Names Protein Names

5'-3' exonuclease PLD4

  • PLD 4

Recombinant PLD4 Proteins

Cat. No. Product Name Accession Purity
HY-P78019 PLD4 Protein, Human (HEK293, His) Q96BZ4 (W52-G506) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Paraurethral Gland Cancer

  • Malignant Tumor Of Paraurethral Gland

  • Malignant Tumor Of The Paraurethral Gland

  • Skene Gland Carcinoma

  • Carcinoma Of The Paraurethral Gland

  • Paraurethral Gland Carcinoma
Nephrotic Syndrome, Type 7

  • Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7

  • NPHS7

  • Nephrotic Syndrome Type 7

  • Ig-Mediated Membranoproliferative Glomerulonephritis

  • Ig-Mediated Mpgn

  • Immunoglobulin-Mediated Mpgn

  • Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical 7

  • Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome With Dgke Deficiency

  • Hus With Dgke Deficiency

  • Hemolytic Uremic Syndrome Atypical 7

  • AHUS7

  • Nephrotic Syndrome 7

  • Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10673 PLD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18149 Pld4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24624 Pld4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLD4 VGNC VGNC:32998
Mus musculus PLD4 MGD MGI:2144765
Macaca mulatta PLD4 VGNC VGNC:76100
Rattus norvegicus PLD4 RGD RGD:1598308
Felis catus PLD4 VGNC VGNC:64214
Canis familiaris PLD4 VGNC VGNC:44663
Others PLD4 NCBI