RNF168 - ring finger protein 168 Gene

Also Known as RIDL; hRNF168

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 165918

About RNF168

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,468,783-196,503,768 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in testis (RPKM 13.5), bone marrow (RPKM 9.5) and 24 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]

RNF168 Products (1)

mRNA	Protein	Name
NM_152617.4	NP_689830.2	E3 ubiquitin-protein ligase RNF168

RNF168 Protein Structure

zf-C3HC4_2

0
100
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300
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571 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF168	RING-type E3 ubiquitin transferase RNF168

RNF168 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RNF168	Q8IYW5	UBE2N	Homo sapiens	P61088	Anti Bait CoIP	19203578
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	RNF168	Q8IYW5	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	RNF168	Q8IYW5	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	RNF168	Q8IYW5	RNF11	Homo sapiens	Q9Y3C5	Y2H	15231748
Intra	RNF168	Q8IYW5	H1-0	Homo sapiens	P07305	Pull Down	26503038

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Riddle Syndrome	RIDL Radiosensitivity-Immunodeficiency-Dysmorphic Features-Learning Difficulties Syndrome Rnf168 Deficiency Radiosensitivity, Immunodeficiency, Dysmorphic Facial Features, And Learning Difficulties Radiosensitivity, Immunodeficiency, Dysmorphic Features, And Learning Difficulties
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Duplication Syndrome	Chromosome 3q29 Microduplication Syndrome Trisomy 3q29 Microduplication 3q29 Syndrome 3q29 Microduplication 3q29 Microduplication Syndrome 3q29 Interstitial Microduplication
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-151799	P62-RNF168 agonist-1		98.03%	Unkown
HY-RS12062	RNF168 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19811	Rnf168 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26307	Rnf168 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF168	RGD	RGD:1585168
Bos taurus	RNF168	VGNC	VGNC:97307
Macaca mulatta	RNF168	VGNC	VGNC:76840
Felis catus	RNF168	VGNC	VGNC:101463
Mus musculus	RNF168	MGD	MGI:1917488
Canis familiaris	RNF168	VGNC	VGNC:45643
Others	RNF168	NCBI