Vkorc1 - vitamin K epoxide reductase complex, subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309004

Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]

Vkorc1 Products (1)

mRNA Protein Name
NM_203335.2 NP_976080.1 vitamin K epoxide reductase complex subunit 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables vitamin-K-epoxide reductase (warfarin-insensitive) activity IDA
IDA: Inferred from direct assay
11341364 RGD
contributes to vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA
IDA: Inferred from direct assay
15640149 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
14765194 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
12832152 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin K epoxide reductase complex subunit 1

  • Warfarin resistance

  • phylloquinone epoxide reductase

  • vitamin K1 2,3-epoxide reductase subunit 1

  • vitamin K1 epoxide reductase (warfarin-sensitive)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-14854A Tecarfarin sodium Inhibitor / Phase 3
HY-14854R Tecarfarin (Standard) Antagonist / Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15659 VKORC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15660 VKORC1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14854S Tecarfarin-13C,d3 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vkorc1 NCBI NCBI:79001