ANO2 - anoctamin 2 Gene

Also Known as C12orf3; TMEM16B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57101

About ANO2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:5,562,655-5,946,232 (from NCBI)

This gene has 12 transcripts (splice variants), 294 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]

ANO2 Products (3)

mRNA	Protein	Name
NM_001278596.3	NP_001265525.1	anoctamin-2 isoform 1
NM_001278597.3	NP_001265526.1	anoctamin-2 isoform 2
NM_001364791.2	NP_001351720.1	anoctamin-2 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	19474308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30126976	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	23576756	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANO2 Protein Structure

Anoctamin

0
200
400
600
800
999 a.a.

Protein Preferred Names	Protein Names
anoctamin-2	anoctamin 2, calcium activated chloride channel

Related Diseases

Diseases	Alias
Von Willebrand Disease, Type 3	Von Willebrand Disease Type 3 VWD3 Von Willebrand'S Disease 3 Von Willebrand Disease Type Iii Von Willebrand Disease, Type Iii Vwd, Type 3 Vwd Type 3 Von Willebrand Disease 3 Von Willebrand Disease Recessive Form Von Willebrand Factor Deficiency Type 3
Gnathodiaphyseal Dysplasia	GDD Osteogenesis Imperfecta With Unusual Skeletal Lesions Gnathodiaphyseal Sclerosis Osteogenesis Imperfecta, Levin Type Levin Syndrome 2 Dysplasia, Gnathodiaphyseal
Miyoshi Muscular Dystrophy 3	MMD3 Miyoshi Myopathy 3 Distal Anoctaminopathy Miyoshi Muscular Dystrophy Type 3 Dystrophy, Muscular, Miyoshi, Type 3
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2l	Lgmd2l Muscular Dystrophy, Limb-Girdle, Type 2l
Scott Syndrome	SCTS Bdplt7 Prothrombin Consumption Deficiency Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X Bleeding Disorder, Platelet-Type, 7 Prothrombin Conversion Defect, Familial Prothrombin Consumption Inhibitor, Familial Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X Familial Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Platelet-Type Bleeding Disorder 7 Platelet Factor X Receptor Deficiency Bleeding Disorder Platelet-Type 7 Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Familial
Spinocerebellar Ataxia, Autosomal Recessive 10	SCAR10 Autosomal Recessive Spinocerebellar Ataxia 10 Adult-Onset Autosomal Recessive Cerebellar Ataxia Autosomal Recessive Spinocerebellar Ataxia Type 10 Spinocerebellar Ataxia, Autosomal Recessive, 10 Ataxia, Spinocerebellar, Autosomal Recessive, Type 10
Miyoshi Muscular Dystrophy	Distal Myopathy Distal Muscular Dystrophy Miyoshi Myopathy Distal Myopathies Dystrophy, Muscular, Miyoshi Myopathy, Distal Distal Muscular Dystrophies
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-146320	ANO1-IN-1	Inhibitor	99.57%	Unkown
HY-146321	ANO1-IN-2	Inhibitor	/	Unkown
HY-RS00742	ANO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22103	Ano2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28624	Ano2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANO2	VGNC	VGNC:25951
Felis catus	ANO2	VGNC	VGNC:59829
Mus musculus	ANO2	MGD	MGI:2387214
Rattus norvegicus	ANO2	RGD	RGD:1591606
Canis familiaris	ANO2	VGNC	VGNC:37925
Others	ANO2	NCBI