New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis

  • Trends Parasitol. 2017 Sep;33(9):662-664. doi: 10.1016/j.pt.2017.07.004.
Honorine D Ward  1
Affiliations
PMID: 28750950 DOI: 10.1016/j.pt.2017.07.004
Abstract

The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium Infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.

Keywords
Cryptosporidium; children; diarrhea; drug discovery; immunocompromised.
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