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IST1 - IST1 factor associated with ESCRT-III Gene

Also Known as OLC1; CHMP8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9798

About IST1

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,894,408-71,931,199 (from NCBI)

This gene has 27 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in bone marrow (RPKM 49.3), gall bladder (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

IST1 Products (6)

mRNA	Protein	Name
NM_001270975.2	NP_001257904.1	IST1 homolog isoform a
NM_001270976.1	NP_001257905.1	IST1 homolog isoform c
NM_001270977.2	NP_001257906.1	IST1 homolog isoform d
NM_001270978.2	NP_001257907.1	IST1 homolog isoform e
NM_001270979.1	NP_001257908.1	IST1 homolog isoform e
NM_014761.4	NP_055576.2	IST1 homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MIT domain binding	IPI IPI: Inferred from physical interaction	19129479	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19525971	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	20719964	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19129479	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in abscission	IDA IDA: Inferred from direct assay	19129479	GOA
involved in abscission	IMP IMP: Inferred from mutant phenotype	19525971	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	19129479	GOA
involved in cytoskeleton-dependent cytokinesis	IMP IMP: Inferred from mutant phenotype	19525971	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	20849418	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	20719964	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Flemming body	IDA IDA: Inferred from direct assay	19129479	GOA
located in centrosome	IDA IDA: Inferred from direct assay	19129479	GOA
located in chromatin	IDA IDA: Inferred from direct assay	28242692	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19129480	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	10942595	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in midbody	IDA IDA: Inferred from direct assay	19129479	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IST1 Protein Structure

Ist1

0
100
200
300
379 a.a.

Protein Preferred Names	Protein Names
IST1 homolog	IST1, ESCRT-III associated factor

IST1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IST1	P53990	CAPN7	Homo sapiens	Q9Y6W3	Anti Tag CoIP	20849418
Intra	IST1	P53990	CAPN7	Homo sapiens	Q9Y6W3	Pull Down	20849418
Intra	IST1	P53990	APEH	Homo sapiens	P13798	Y2H Prey Pooling	25416956
Intra	IST1	P53990	APEH	Homo sapiens	P13798	Validated Y2H	25416956
Intra	IST1	P53990	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	IST1	P53990	VPS9D1	Homo sapiens	Q9Y2B5	Anti Tag CoIP	35271311
Intra	IST1	P53990	ATXN1	Homo sapiens	P54253	Y2H Array	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gastric Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Stomach Squamous Cell Carcinoma Of The Stomach
Spastic Paraplegia 20, Autosomal Recessive	Troyer Syndrome SPG20 Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting Spastic Paraplegia, Autosomal Recessive, Troyer Type Autosomal Recessive Spastic Paraplegia Type 20 Autosomal Recessive Hereditary Spastic Paraplegia Spastic Paraplegia 20 Cross-Mckusick Syndrome Autosomal Recessive Spastic Paraplegia 20 Autosomal Recessive Spastic Paraplegia Troyer Type Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting Hereditary Spastic Paraplegia 20 Spastic Paraplegia Type 20 Hereditary Spastic Paraplegia Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting Spastic Paraplegia Autosomal Recessive Troyer Type Trs Spastic Paraplegia Hereditary Autosomal Recessive Spastic Paraplegia, Hereditary
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06939	IST1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17370	Ist1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23824	Ist1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IST1	VGNC	VGNC:73675
Canis familiaris	IST1	VGNC	VGNC:49862
Rattus norvegicus	IST1	RGD	RGD:1307799
Bos taurus	IST1	VGNC	VGNC:30304
Felis catus	IST1	VGNC	VGNC:62980
Mus musculus	IST1	MGD	MGI:1919205
Others	IST1	NCBI