42924-53-8
42924-53-8
Chemical Structure
Nabumetone
Synonym(s): BRL14777
- CAS No.: 42924-53-8
- Formula:C15H16O2
- Molecular Weight:228.29
IUPAC Name: 4-(6-methoxynaphthalen-2-yl)butan-2-one
InChIKey: BLXXJMDCKKHMKV-UHFFFAOYSA-N
SMILES: CC(CCC1=CC=C2C=C(OC)C=CC2=C1)=O
Biological Activity: Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Nabumetone | 99.94% | Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers. | ||||||||||||||||||||
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Nabumetone (Standard) | ≥98% | Nabumetone (Standard) is the analytical standard of Nabumetone (HY-B0559). This product is intended for research and analytical applications. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers. | ||||||||||||||||||||
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Nabumetone-d3 | 98.80% | Nabumetone-d3 is the deuterium labeled Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers. | ||||||||||||||||||||
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References
- [1]. Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6. [Content Brief]
- [2]. Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. Agents Actions. 1992;Spec No:C82-3. [Content Brief]
- [3]. Yıldırım E, et al. Effects of nabumetone and dipyrone on experimentally induced gastric ulcers in rats. Inflammation. 2013 Apr;36(2):476-81. [Content Brief]
