TMEM106A - transmembrane protein 106A Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113277

About TMEM106A

This gene has 8 transcripts (splice variants) and 111 orthologues. Broad expression in kidney (RPKM 9.2), appendix (RPKM 4.7) and 23 other tissues.

Summary

Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM106A Products (4)

mRNA Protein Name
NM_001291586.2 NP_001278515.1 transmembrane protein 106A isoform a
NM_001291587.2 NP_001278516.1 transmembrane protein 106A isoform b
NM_001291588.2 NP_001278517.1 transmembrane protein 106A isoform c
NM_145041.4 NP_659478.1 transmembrane protein 106A isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM106A Protein Structure

DUF1356

DUF1356: Protein of unknown function (DUF1356) (13 - 252)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

transmembrane protein 106A

TMEM106A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TMEM106A Q96A25 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
TMEM106A Q96A25 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
TMEM106A Q96A25 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
TMEM106A Q96A25 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
TMEM106A Q96A25 TMEM106C Homo sapiens Q9BVX2
Anti Tag CoIP
33961781
Intra
TMEM106A Q96A25 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hereditary Breast Ovarian Cancer Syndrome

  • Hereditary Breast And Ovarian Cancer Syndrome

  • Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

  • Breast And/Or Ovarian Cancer

  • Breast And Ovarian Cancer Syndrome

  • Hboc Syndrome

  • Hereditary Breast And Ovarian Cancer

  • Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14645 TMEM106A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM106A VGNC VGNC:47446
Rattus norvegicus TMEM106A RGD RGD:1309043
Bos taurus TMEM106A VGNC VGNC:35944
Mus musculus TMEM106A MGD MGI:1922056
Macaca mulatta TMEM106A VGNC VGNC:79695
Felis catus TMEM106A VGNC VGNC:66256
Others TMEM106A NCBI