SNX20 - sorting nexin 20 Gene

Also Known as SLIC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124460

About SNX20

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,666,300-50,681,312 (from NCBI)

This gene has 4 transcripts (splice variants), 186 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 7.6), appendix (RPKM 6.3) and 12 other tissues.

Summary

SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

SNX20 Products (3)

mRNA Protein Name
NM_001144972.2 NP_001138444.1 sorting nexin-20 isoform 3
NM_153337.3 NP_699168.1 sorting nexin-20 isoform 2
NM_182854.4 NP_878274.1 sorting nexin-20 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX20 Protein Structure

PX

PX: PX domain (87 - 185)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

sorting nexin-20

  • selectin ligand-interactor cytoplasmic 1

SNX20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SNX20 Q7Z614 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
SNX20 Q7Z614 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
SNX20 Q7Z614 SELPLG Homo sapiens Q14242
Confocal
18196517
Intra
SNX20 Q7Z614 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
SNX20 Q7Z614 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
SNX20 Q7Z614 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
SNX20 Q7Z614 TACC3 Homo sapiens Q9Y6A5
Y2H Array
25416956
Intra
SNX20 Q7Z614 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra
SNX20 Q7Z614 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra
SNX20 Q7Z614 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
25416956
Intra
SNX20 Q7Z614 KLHL12 Homo sapiens Q53G59
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

  • Neutrophil Immunodeficiency Syndrome

  • IMD73A

  • Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis

  • Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis

  • Rac 2 Deficiency
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13534 SNX20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21762 Snx20 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SNX20 MGD MGI:1918857
Felis catus SNX20 VGNC VGNC:65551
Macaca mulatta SNX20 VGNC VGNC:77796
Bos taurus SNX20 VGNC VGNC:35101
Canis familiaris SNX20 VGNC VGNC:46630
Rattus norvegicus SNX20 RGD RGD:1307787
Others SNX20 NCBI