Slc22a3 - solute carrier family 22 (organic cation transporter), member 3 Gene

Also Known as EMT; Oct3; Orct3; Slca22a3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20519

Summary

Enables neurotransmitter transmembrane transporter activity and quaternary ammonium group transmembrane transporter activity. Involved in dopamine transport; histamine transport; and serotonin transport. Acts upstream of or within several processes, including cation transport; quaternary ammonium group transport; and regulation of appetite. Located in neuronal cell body. Is expressed in several structures, including brain; dermis; extraembryonic component; genitourinary system; and thymus primordium. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a3 Products (1)

mRNA Protein Name
NM_011395.2 NP_035525.1 solute carrier family 22 member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables monoamine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
18513366 MGI
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
18513366 MGI
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
10966924 MGI
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
10966924 MGI
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
28543680 MGI
Biological Process GO Annotation Evidence Références Source
involved in dopamine transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
16061728 MGI
acts upstream of or within histamine transport IMP
IMP: Inferred from mutant phenotype
16061728 MGI
involved in histamine transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
acts upstream of or within histamine uptake IMP
IMP: Inferred from mutant phenotype
16061728 MGI
acts upstream of or within monoamine transport IMP
IMP: Inferred from mutant phenotype
11390648 MGI
acts upstream of or within monocarboxylic acid transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
acts upstream of or within neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
involved in norepinephrine transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
acts upstream of or within organic cation transport IDA
IDA: Inferred from direct assay
10966924 MGI
acts upstream of or within organic hydroxy compound transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
acts upstream of or within quaternary ammonium group transport IDA
IDA: Inferred from direct assay
10966924 MGI
acts upstream of or within regulation of appetite IMP
IMP: Inferred from mutant phenotype
15028779 MGI
involved in serotonin transport IMP
IMP: Inferred from mutant phenotype
18513366 MGI
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15817714 MGI
located in endomembrane system IDA
IDA: Inferred from direct assay
27659446 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
27659446 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
18513366 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15817714 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 22 member 3

  • organic cation transporter 3

  • solute carrier family 22, member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13074 SLC22A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a3 NCBI NCBI:6581