2. Gene
  3. SLC22A3 - solute carrier family 22 member 3 Gene

SLC22A3 - solute carrier family 22 member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EMT; EMTH; OCT3

Gene ID: 6581 | Gene type: protein coding

About SLC22A3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,348,378-160,452,577 (from NCBI)

This gene has 1 transcript (splice variant), 527 orthologues and 22 paralogues. Biased expression in liver (RPKM 29.4), prostate (RPKM 6.3) and 10 other tissues.

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

SLC22A3 Products(1)

mRNA Protein Name
NM_021977.4 NP_068812.1 solute carrier family 22 member 3

SLC22A3 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (159 - 485)

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  • 556 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 3

EMT organic cation transporter 3

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8
Extragonadal Seminoma

Primary Extragonadal Seminoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13074 SLC22A3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC22A3 VGNC VGNC:34727
Mus musculus SLC22A3 MGD MGI:1333817
Macaca mulatta SLC22A3 VGNC VGNC:77418
Canis familiaris SLC22A3 VGNC VGNC:46278
Felis catus SLC22A3 VGNC VGNC:65245
Rattus norvegicus SLC22A3 RGD RGD:3701