SLC22A3 - solute carrier family 22 member 3 Gene

Also Known as EMT; EMTH; OCT3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6581

About SLC22A3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,348,378-160,452,577 (from NCBI)

This gene has 1 transcript (splice variant), 527 orthologues and 22 paralogues. Biased expression in liver (RPKM 29.4), prostate (RPKM 6.3) and 10 other tissues.

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

SLC22A3 Products (1)

mRNA	Protein	Name
NM_021977.4	NP_068812.1	solute carrier family 22 member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10196521	GOA
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23505051	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	10196521	GOA
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23505051	GOA
enables organic cation transmembrane transporter activity	EXP EXP: Inferred from Experiment	19141712	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	10966924	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	10966924	GOA
enables toxin transmembrane transporter activity	IDA IDA: Inferred from direct assay	22806583	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular detoxification	IDA IDA: Inferred from direct assay	22806583	GOA
involved in dopamine transport	IDA IDA: Inferred from direct assay	16581093	GOA
involved in dopamine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in epinephrine transport	IDA IDA: Inferred from direct assay	10196521	GOA
involved in epinephrine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in histamine transport	IDA IDA: Inferred from direct assay	16581093	GOA
involved in histamine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in histamine uptake	IMP IMP: Inferred from mutant phenotype	23505051	GOA
involved in monoamine transport	IMP IMP: Inferred from mutant phenotype	23505051	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	20858707	GOA
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	10196521	GOA
involved in norepinephrine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
acts upstream of or within organic cation transport	IDA IDA: Inferred from direct assay	10966924	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	22806583	GOA
acts upstream of or within quaternary ammonium group transport	IDA IDA: Inferred from direct assay	10966924	GOA
involved in quaternary ammonium group transport	IDA IDA: Inferred from direct assay	20858707	GOA
involved in serotonin transport	IDA IDA: Inferred from direct assay	10196521	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	20858707	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15817714	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20858707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A3 Protein Structure

MFS_1

0
100
200
300
400
500
556 a.a.

Protein Preferred Names	Protein Names
solute carrier family 22 member 3	EMT organic cation transporter 3

SLC22A3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83085	SLC22A3 Antibody (YA2830)	WB, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Type 1 Diabetes Mellitus 8	Diabetes Mellitus, Insulin-Dependent, 8 Iddm8 Insulin-Dependent Diabetes Mellitus 8 T1D8 Insulin-Dependent Diabetes Mellitus-8
Extragonadal Seminoma	Primary Extragonadal Seminoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13074	SLC22A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC22A3	VGNC	VGNC:34727
Mus musculus	SLC22A3	MGD	MGI:1333817
Macaca mulatta	SLC22A3	VGNC	VGNC:77418
Canis familiaris	SLC22A3	VGNC	VGNC:46278
Felis catus	SLC22A3	VGNC	VGNC:65245
Rattus norvegicus	SLC22A3	RGD	RGD:3701