Asxl1 - ASXL transcriptional regulator 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228790

Summary

Enables peroxisome proliferator activated receptor binding activity; retinoic acid receptor binding activity; and transcription coactivator activity. Involved in several processes, including kidney development; negative regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within animal organ development; cell morphogenesis; and homeostasis of number of cells. Located in nucleus. Is expressed in several structures, including limb bud; lung; nervous system; paraxial mesenchyme; and salivary gland. Used to study acute myeloid leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Asxl1 Products (1)

mRNA Protein Name
NM_001039939.2 NP_001035028.1 polycomb group protein ASXL1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables nuclear retinoic acid receptor binding IDA
IDA: Inferred from direct assay
16606617 MGI
enables peroxisome proliferator activated receptor binding IDA
IDA: Inferred from direct assay
21047783 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16606617 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16606617 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
22876197 MGI
acts upstream of or within bone marrow development IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
24860998 MGI
acts upstream of or within hematopoietic or lymphoid organ development IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
19861679 MGI
acts upstream of or within lung saccule development IMP
IMP: Inferred from mutant phenotype
24860998 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
21047783 MGI
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: Inferred from direct assay
21047783 MGI
involved in podocyte development IMP
IMP: Inferred from mutant phenotype
26385183 MGI
involved in positive regulation of retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
16606617 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16606617 MGI
involved in regulation of kidney size IMP
IMP: Inferred from mutant phenotype
26385183 MGI
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
16606617 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
19861679 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
24216483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb group protein ASXL1

  • additional sex combs like 1

  • additional sex combs-like protein 1

  • putative Polycomb group protein ASXL1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W327122 BAP1-IN-1 Inhibitor 99.86% Unkown
HY-RS01114 ASXL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17970 Asxl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24441 Asxl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asxl1 NCBI NCBI:171023