ASXL1 - ASXL transcriptional regulator 1 Gene

Also Known as MDS; BOPS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 171023

About ASXL1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,358,331-32,439,319 (from NCBI)

This gene has 26 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 150 phenotypes. Ubiquitous expression in testis (RPKM 13.2), lymph node (RPKM 9.6) and 25 other tissues.

Summary

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and Other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of Other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

ASXL1 Products (3)

mRNA	Protein	Name
NM_001164603.1	NP_001158075.1	polycomb group protein ASXL1 isoform 2
NM_001363734.1	NP_001350663.1	polycomb group protein ASXL1 isoform 3
NM_015338.6	NP_056153.2	polycomb group protein ASXL1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16606617	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PR-DUB complex	IDA IDA: Inferred from direct assay	20436459	GOA
part of PR-DUB complex	IPI IPI: Inferred from physical interaction	20436459	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASXL1 Protein Structure

HARE-HTH

ASXH

PHD_3

0
300
600
900
1200
1541 a.a.

Protein Preferred Names	Protein Names
polycomb group protein ASXL1	additional sex combs like 1, transcriptional regulator

ASXL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASXL1	Q8IXJ9	BAP1	Homo sapiens	Q92560	Anti Bait CoIP	22897849
Intra	ASXL1	Q8IXJ9	BAP1	Homo sapiens	Q92560	TAP	27705803
Intra	ASXL1	Q8IXJ9	BAP1	Homo sapiens	Q92560	Anti Tag CoIP	22897849
Intra	ASXL1	Q8IXJ9	AKT1	Homo sapiens	P31749	Y2H	18624398
Intra	ASXL1	Q8IXJ9	AKT1	Homo sapiens	P31749	Anti Tag CoIP	18624398
Cross	ASXL1	Q8IXJ9	Rxra	Mus musculus	P28700	Y2H	16606617
Intra	ASXL1	Q8IXJ9	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	22897849
Intra	ASXL1	Q8IXJ9	EZH2	Homo sapiens	Q15910	Anti Tag CoIP	22897849
Intra	ASXL1	Q8IXJ9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ASXL1	Q8IXJ9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ASXL1	Q8IXJ9	ESR1	Homo sapiens	P03372	Pull Down	16606617
Intra	ASXL1	Q8IXJ9	ESR1	Homo sapiens	P03372	Y2H	16606617
Intra	ASXL1	Q8IXJ9	EED	Homo sapiens	O75530	Anti Bait CoIP	22897849
Cross	ASXL1	Q8IXJ9	THRB	Gallus gallus	P68306	Y2H	16606617
Cross	ASXL1	Q8IXJ9	THRB	Gallus gallus	P68306	Pull Down	16606617

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASXL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7614	ASXL1 Protein, Human (GST)	Q8IXJ9-1 (K1477-R1541)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Bohring-Opitz Syndrome	C-Like Syndrome Bohring Syndrome Opitz Trigonocephaly-Like Syndrome BOPS Oberklaid-Danks Syndrome Bos Bos Syndrome
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Systemic Mastocytosis With Associated Hematologic Neoplasm	Systemic Mastocytosis With An Associated Clonal Hematologic Non-Mast Cell Lineage Disease Sm-Ahn Sm-Ahnmd Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease
Hypertrichosis
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Rubinstein Taybi Like Syndrome	Broad Terminal Phalanges Of The Thumbs And Great Toes, Antimongoloid Slant Of The Palpebral Fissures, And Characteristic Beaked Noses
Refractory Anemia With Excess Blasts	Raeb
Refractory Anemia	Anemia Refractory Refractory Anemias Refractory Anemia, Without Ringed Sideroblasts, Without Excess Blasts Refractory Anaemia Without Sideroblasts Refractory Anaemia With Sideroblasts Acquired Idiopathic Sideroblastic Anaemia Primary Acquired Sideroblastic Anaemia Refractory Sideroblastic Anaemia Refractory Anaemia With Excess Blasts Raeb - [Refractory Anaemia With Excess Blasts] Nos Raeb - [Refractory Anaemia With Excess Blasts] Rars-T [Refractory Anaemia With Ringed Sideroblasts Associated With Marked Thrombocytosis]
Refractory Cytopenia With Multilineage Dysplasia
Mastocytosis, Cutaneous	Urticaria Pigmentosa Cutaneous Mastocytosis Diffuse Cutaneous Mastocytosis Maculopapular Cutaneous Mastocytosis Mastocytosis, Diffuse Cutaneous MASTC Mastocytosis, Maculopapular Cutaneous Mastocytosis, Systemic, Somatic Mastocytoma Dcm Diffuse Cutaneous Maculopapulous Mastocytosis Up/Mpcm Cm Mastocytosis, Systemic MASTSYS Mast Cell Disease Mast-Cell Disease Mast Cell Leukemia Mastocytosis, Indolent Mastocytosis With Associated Hematologic Disorder Mast Cell Neoplasm Benign Mastocytoma
Exophthalmos	Proptosis
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Myelophthisic Anemia	Myelophthisis Anemia Leukoerythroblastic Anemia, Leukoerythroblastic Leukoerythroblastosis Anemia, Myelophthisic Leukoerythroblastic Anemia
Thrombocytosis	Thrombocythaemia
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Immunodeficiency 21	Monocytopenia And Mycobacterial Infection Syndrome Monomac Gata2 Deficiency Monocytopenia With Susceptibility To Infections Dcml IMD21 Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections Monocyte - B - Natural Killer - Dendritic Cell Deficiency Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia
Bainbridge-Ropers Syndrome	BRPS Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome Asxl3-Related Disorder
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Sm-Ahnmd	Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Chronic Neutrophilic Leukemia	Cnl Leukemia Neutrophilic Chronic
Diamond-Blackfan Anemia 11	DBA11 Rpl26-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 11
Indolent Systemic Mastocytosis	Ism
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Alpha-Thalassemia Myelodysplasia Syndrome	ATMDS Acquired Hemoglobin H Disease Alpha-Thalassemia Myelodysplasia Syndrome, Somatic Acquired Hbh Disease Alpha-Thalassemia-Myelodysplastic Syndrome Hemoglobin H Disease, Acquired Acquired Alpha-Thalassemia With Myelodysplastic Syndrome Hemoglobin H Disease Acquired Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Extracutaneous Mastocytoma	Mastocytoma Mast Cell Neoplasm Benign Mastocytoma
Mast-Cell Sarcoma	Mast Cell Sarcoma
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Core Binding Factor Acute Myeloid Leukemia	Cbf Acute Myeloid Leukemia Cbf-Aml Core-Binding Factor Aml
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Patau Syndrome	Trisomy 13 Complete Trisomy 13 Syndrome Trisomy 13 Syndrome D1 Trisomy Patau'S Syndrome Complete Trisomy 13 Chromosome 13, Trisomy 13 Complete D Trisomy Syndrome Bartholin-Patau Syndrome Chromosome 13 Duplication D1 Trisomy Syndrome D>1< Trisomy Syndrome Patau Chromosome 13 Trisomy Abnormal Autosomes 13
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Vexas Syndrome	VEXAS Vexas Syndrome, Somatic Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Mast Cell Neoplasm	Mastocytoma Mast Cell Proliferative Disease Mast Cell Tumor Benign Mastocytoma
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Hematuria, Benign Familial	Benign Familial Hematuria BFH Thin Membrane Nephropathy Tmn Thin Basement Membrane Nephropathy Thin-Basement-Membrane Nephropathy Hematuria, Familial Benign Hematuria Benign Familial Hematuria, Benign, Familial Thin Basement Membrane Disease
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W327122	BAP1-IN-1	Inhibitor	99.86%	Unkown
HY-RS01114	ASXL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17970	Asxl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24441	Asxl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASXL1	VGNC	VGNC:26228
Canis familiaris	ASXL1	VGNC	VGNC:38196
Macaca mulatta	ASXL1	VGNC	VGNC:70095
Rattus norvegicus	ASXL1	RGD	RGD:1561878
Felis catus	ASXL1	VGNC	VGNC:59984
Mus musculus	ASXL1	MGD	MGI:2684063
Others	ASXL1	NCBI