TMEM98 - transmembrane protein 98 Gene

Also Known as TADA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26022

About TMEM98

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,928,153-32,944,315 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 69.4), endometrium (RPKM 44.6) and 23 other tissues.

Summary

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

TMEM98 Products (3)

mRNA	Protein	Name
NM_001033504.2	NP_001028676.1	transmembrane protein 98
NM_001301746.2	NP_001288675.1	transmembrane protein 98
NM_015544.3	NP_056359.2	transmembrane protein 98

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	25946230	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25946230	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25946230	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM98 Protein Structure

GCIP

0
100
200
226 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 98

TMEM98 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TMEM98	Q9Y2Y6	ATP1B3	Homo sapiens	P54709	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	ATP1B3	Homo sapiens	P54709	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	TMEM98	Q9Y2Y6	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	TMEM98	Q9Y2Y6	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nanophthalmos 4	NNO4 Nanophthalmia 4 Nanophthalmos, Type 4
Nanophthalmos	Nanophthalmia
Aqueous Misdirection
Interval Angle-Closure Glaucoma	Intermittent Angle-Closure Glaucoma Angle-Closure Glaucoma, Subacute Prodromal Angle Closure Glaucoma
Microphthalmia, Isolated 6	Isolated Microphthalmia 6 MCOP6 Microphthalmia, Posterior Nonsyndromic Posterior Nonsyndromic Microphthalmia Microphthalmia, Isolated, 6 Autosomal Recessive Posterior Microphthalmos Posterior Non-Syndromic Microphthalmia Microphthalmia, Isolated, Type 6
Farsightedness	Hypermetropia Hyperopia Far-Sightedness Farsighted Long-Sighted Long-Sightedness
Bullous Retinoschisis
Kenny-Caffey Syndrome	Kenny Syndrome
Optic Disk Drusen	Optic Disc Drusen Drusen Of Optic Disc Optic Nerve Head Drusen Drusen Optic Disc
Kenny-Caffey Syndrome, Type 2	KCS2 Kenny-Caffey Syndrome Type 2 Autosomal Dominant Kenny-Caffey Syndrome Kenny Syndrome Dwarfism, Cortical Thickening Of Tubular Bones, And Transient Hypocalcemia Dwarfism, Cortical Thickening Of Tubular Bones And Transient Hypocalcemia Kenny-Caffey Syndrome, Autosomal Dominant Kenny-Caffey Syndrome 2 Dwarfism With Cortical Thickening Of Tubular Bones And Transient Hypocalcemia Kenny-Caffey Syndrome
Isolated Microphthalmia
Vitreoretinochoroidopathy	Autosomal Dominant Vitreoretinochoroidopathy Advirc Vitreoretinochoroidopathy With Microcornea, Glaucoma, And Cataract Vitreoretinochoroidopathy, Autosomal Dominant, With Nanophthalmos Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 2 Vitreoretinochoroidopathy Dominant VRCP Vitreoretinochoroidopathy, Autosomal Dominant Vrcp Autosomal Dominant Vitreoretinochoroidopathy Autosomal Dominant With Nanophthalmos, Microcornea, Rod-Cone Dystrophy, Cataract And Posterior Staphyloma Vitreoretinochoroidopathy With Microcornea-Glaucoma-Cataract
Acute Closed-Angle Glaucoma	Acute Angle-Closure Glaucoma
Total Anomalous Pulmonary Venous Return 1	Scimitar Syndrome Total Anomalous Pulmonary Venous Return Anomalous Pulmonary Venous Return Scimitar Anomaly TAPVR1 Apvr Halasz Syndrome Hypogenetic Lung Syndrome Pulmonary Venolobar Syndrome TAPVR Congenital Total Pulmonary Venous Return Anomaly Congenital Venolobar Syndrome Mirror-Image Lung Syndrome Vena Cava Bronchovascular Syndrome Pulmonary Venous Return Anomaly Congenital Pulmonary Venolobar Syndrome Epibronchial Right Pulmonary Vein Syndrome
Diaphragm Disease	Abnormality Of The Diaphragm Disease Of Diaphragm Diaphragmatic Disorder Disorder Of Diaphragm
Primary Angle-Closure Glaucoma	Primary Angle Closure Glaucoma Angle Closure Glaucoma Acg - [Angle Closure Glaucoma] Angle-Closure Glaucoma Closed Angle Glaucoma Acute Glaucoma Prodromal Angle Closure Glaucoma
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Refractive Error	Refractive Errors
Fundus Albipunctatus	Retinitis Punctata Albescens Pigmentary Retinal Dystrophy RPA Albipunctate Retinal Dystrophy Lauber'S Disease FALBI Fa
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14753	TMEM98 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM98	RGD	RGD:1359736
Felis catus	TMEM98	VGNC	VGNC:66374
Macaca mulatta	TMEM98	VGNC	VGNC:99306
Mus musculus	TMEM98	MGD	MGI:1923457
Bos taurus	TMEM98	VGNC	VGNC:36130
Canis familiaris	TMEM98	VGNC	VGNC:47618
Others	TMEM98	NCBI