MCAT - malonyl-CoA-acyl carrier protein transacylase Gene

Also Known as MT; MCT; MCT1; fabD; NET62; FASN2C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27349

About MCAT

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,132,206-43,143,398 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 9.6), testis (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

MCAT Products (2)

mRNA	Protein	Name
NM_014507.3	NP_055322.1	malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor
NM_173467.5	NP_775738.3	malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables [acyl-carrier-protein] S-malonyltransferase activity	IDA IDA: Inferred from direct assay	12882974	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	12882974	GOA
involved in mitochondrial small ribosomal subunit assembly	IDA IDA: Inferred from direct assay	36482135	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	12882974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCAT Protein Structure

Acyl_transf_1

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
malonyl-CoA-acyl carrier protein transacylase, mitochondrial	[Acyl-carrier-protein] malonyltransferase

Related Diseases

Diseases	Alias
Autosomal Recessive Isolated Optic Atrophy	Autosomal Recessive Non-Syndromic Optic Atrophy
Optic Atrophy 6	OPA6 Optic Atrophy, Congenital Or Early Infantile, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-15533	LY 3000328	Inhibitor	99.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS08216	MCAT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21371	Mcat Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27890	Mcat Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCAT	VGNC	VGNC:43069
Felis catus	MCAT	VGNC	VGNC:63410
Macaca mulatta	MCAT	VGNC	VGNC:74616
Mus musculus	MCAT	MGD	MGI:2388651
Rattus norvegicus	MCAT	RGD	RGD:1306698
Bos taurus	MCAT	VGNC	VGNC:31297