CWC15 - CWC15 spliceosome associated protein homolog Gene

Also Known as ORF5; AD002; Cwf15; C11orf5; HSPC148

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51503

About CWC15

This gene has 6 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 28.4), bone marrow (RPKM 17.4) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in mitochondrion and nuclear speck. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CWC15 Products (3)

mRNA Protein Name
NM_001363371.2 NP_001350300.1 spliceosome-associated protein CWC15 homolog
NM_001363372.2 NP_001350301.1 spliceosome-associated protein CWC15 homolog
NM_016403.4 NP_057487.2 spliceosome-associated protein CWC15 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
20176811 GOA
Biological Process GO Annotation Evidence Références Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
Cellular Component GO Annotation Evidence Références Source
part of Prp19 complex IPI
IPI: Inferred from physical interaction
20176811 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20176811 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
20176811 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
20176811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CWC15 Protein Structure

Cwf_Cwc_15

Cwf_Cwc_15: Cwf15/Cwc15 cell cycle control protein (1 - 228)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

spliceosome-associated protein CWC15 homolog

  • CWC15 spliceosome-associated protein

CWC15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CWC15 Q9P013 CTNNBL1 Homo sapiens Q8WYA6
Y2H
22365833
Intra
CWC15 Q9P013 CTNNBL1 Homo sapiens Q8WYA6
Anti Tag CoIP
20176811
Intra
CWC15 Q9P013 CTNNBL1 Homo sapiens Q8WYA6
Far-WB
20176811
Intra
CWC15 Q9P013 CTNNBL1 Homo sapiens Q8WYA6
Pull Down
20176811
Intra
CWC15 Q9P013 CTNNBL1 Homo sapiens Q8WYA6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Actinobacillosis
Noonan Syndrome 12

  • NS12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03372 CWC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22462 Cwc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28985 Cwc15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CWC15 VGNC VGNC:56100
Rattus norvegicus CWC15 RGD RGD:1310669
Felis catus CWC15 VGNC VGNC:82006
Macaca mulatta CWC15 VGNC VGNC:100916
Bos taurus CWC15 VGNC VGNC:54863
Mus musculus CWC15 MGD MGI:1913320
Others CWC15 NCBI