154889-68-6
Chemical Structure
Pibrozelesin
Synonym(s): KW 2189 free base
- CAS. Nr.: 154889-68-6
- Formula:C32H36BrN5O8
- Molecular Weight:698.56
IUPAC Name: (S)-methyl 8-(bromomethyl)-2-methyl-4-((4-methylpiperazine-1-carbonyl)oxy)-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate
InChIKey: QRMNENFZDDYDEF-GOSISDBHSA-N
SMILES: BrC[C@H]1C2=C(N(C1)C(C(NC3=C4OC)=CC3=CC(OC)=C4OC)=O)C=C(OC(N5CCN(CC5)C)=O)C6=C2C(C(OC)=O)=C(C)N6
Biological Activity: Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase[1].
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Pibrozelesin | Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase. | |||||||||||||||||||||
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Keywords
