136765-50-9
136765-50-9
Chemical Structure
Protriptyline-d3
- CAS No.: 136765-50-9
- Formula:C19H18D3N
- Molecular Weight:266.40
IUPAC Name: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-(methyl-d3)propan-1-amine
InChIKey: BWPIARFWQZKAIA-FIBGUPNXSA-N
SMILES: [2H]C([2H])([2H])NCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3
Biological Activity: Protriptyline-d3 is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].
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Protriptyline-d3 | Protriptyline-d3 is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease. | |||||||||||||||||||||
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Protriptyline | Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196.
- [3]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. [Content Brief]
Keywords
