3103984-17-1
Chemical Structure
TEAD degrader-1
- CAS No.: 3103984-17-1
- Formula:C36H38ClF2N3O6
- Molecular Weight:682.15
InChIKey: RSNBMCBGVJCYMG-JHGBDTQUSA-N
SMILES: O=C(N)C1=[C@]([C@]2=C(Cl)C(F)=CC3=C2[C@H](C)[C@](C4=CC=CC=C4)(CN[C@@H]5CC[C@@H](C(N6CC(C=O)OCC6)=O)CC5)O3)C(F)=C(OC)C=C1
Biological Activity: TEAD degrader-1 is a potent FBXO22-mediated molecular glue degrader of TEAD, with a 24 h DC50 of 1.0 nM. TEAD degrader-1 binds reversibly and covalently to FBXO22 C326, assembles a functional ternary complex, and mediates proteasomal degradation of TEAD. TEAD degrader-1 exhibits high selectivity for the Hippo pathway and specifically downregulates only TEAD and its downstream target proteins. TEAD degrader-1 is applicable to research related to malignant pleural mesothelioma and non-small cell lung cancer[1].
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TEAD degrader-1 | TEAD degrader-1 is a potent FBXO22-mediated molecular glue degrader of TEAD, with a 24 h DC50 of 1.0 nM. TEAD degrader-1 binds reversibly and covalently to FBXO22 C326, assembles a functional ternary complex, and mediates proteasomal degradation of TEAD. TEAD degrader-1 exhibits high selectivity for the Hippo pathway and specifically downregulates only TEAD and its downstream target proteins. TEAD degrader-1 is applicable to research related to malignant pleural mesothelioma and non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
