509-96-6
Chemical Structure
Rotenolone
- CAS No.: 509-96-6
- Formula:C23H22O7
- Molecular Weight:410.42
IUPAC Name: (2R,6aR,12aR)-6a-hydroxy-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
InChIKey: JFVKWCYZKMUTLH-AYPBNUJASA-N
SMILES: O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(C)=C)COC5=C2C=C(C(OC)=C5)OC)O
Biological Activity: Rotenolone is a metabolite of Rotenone (HY-B1756), inhibitor of Mitochondrial complex I, and antiproliferative agent, with an IC50 of 137 nM against bovine complex I. Rotenolone undergoes biotransformation via multiple cytochrome P450 isoenzymes in rainbow trout liver microsomes. Rotenolone exhibits anticancer activity against ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. Rotenolone can be used in studies related to ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Rotenolone | 97.0% | Rotenolone is a metabolite of Rotenone (HY-B1756), inhibitor of Mitochondrial complex I, and antiproliferative agent, with an IC50 of 137 nM against bovine complex I. Rotenolone undergoes biotransformation via multiple cytochrome P450 isoenzymes in rainbow trout liver microsomes. Rotenolone exhibits anticancer activity against ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. Rotenolone can be used in studies related to ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Erickson D A, et al. Biotransformation of rotenone by hepatic microsomes following pretreatment of rainbow trout with inducers of cytochrome P450[J]. Pesticide biochemistry and physiology, 1992, 42(2): 140-150.
- [2]. Harinantenaina L, et al. Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest. J Nat Prod. 2010;73(9):1559-1562. [Content Brief]
- [3]. Russell DA, et al. Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells. J Nat Prod. 2020;83(6):1829-1845. [Content Brief]
Keywords
